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Review

Development of Diagnostic, Treatment and Control Technologies Based on Big Data for Infectious Viruses in Marine Environments

해양 환경 내 감염성 바이러스 빅데이터 기반 진단, 치료 및 제어 기술 개발

TAEK-KYUN LEE1*
,
SEUNG WON JUNG2
,
WON-KEUN KIM3
,
SUKCHAN LEE4
,
SOO-JIN HEO5
,
TAE-JIN CHOI6
,
YOUNG-JUN KIM7
,
MIN-JEONG KIM8
이 택견1*
,
정 승원2
,
김 원근3
,
이 석찬4
,
허 수진5
,
최 태진6
,
김 영준7
,
김 민정8
1Principal Research Scientist, Ecological Risk Research Department, Korea Institute of Ocean Science & Technology, Geoje 53201, Korea
2Principal Research Scientist, Library of Marine Samples, Korea Institute of Ocean Science & Technology, Geoje 53201, Korea
3Associate Professor, Department of Microbiology, College of Medicine, Hallym University, Chuncheon 24252, Korea
4Professor, Department of Integrative Biotechnology, Sungkyunkwan University, Suwon 16419, Korea
5Principal Research Scientist, Jeju Bio Research Center, Korea Institute of Ocean Science and Technology (KIOST), Jeju 63349, Korea
6Professor, Department of Microbiology, School of Marine and Fisheries Sciences, Pukyong National University, Busan 48513, Korea
7Director of the Research Institute, R&D Center, Novelgen Co., Ltd., Suwon 16229, Korea
8Postdoctoral Researcher, Library of Marine Samples, Korea Institute of Ocean Science & Technology, Geoje 53201, Korea
1한국해양과학기술원 생태위해성연구부 책임연구원
2한국해양과학기술원 시료도서관 책임연구원
3한림대학교 의예·의학과 부교수
4성균관대학교 융합과학대학 교수
5한국해양과학기술원 제주연구소 책임연구원
6부경대학교 미생물학과 교수
7㈜노블젠 연구소장
8한국해양과학기술원 시료도서관 연수연구원
*Corresponding Author
28 February 2025. pp. 63-79
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Abstract

In the 21st century, the occurrence of various infectious diseases caused by viruses has increased. Since 2010, viruses such as Zika, avian influenza, and coronaviruses (SARS, MERS, etc.) have caused significant loss of life and substantial socioeconomic damage. In particular, COVID-19, which emerged in 2019, led to a global pandemic in 2020 and has persisted with no clear resolution. The World Health Organization (WHO) has warned of the need to prepare for future pandemics caused by unknown diseases, designating such threats as “Disease X.” Covering more than 70% of the Earth’s surface and hosting over 80% of its biosphere, the oceans are expected to harbor a significantly higher diversity of viruses compared to terrestrial environments. These viruses are believed to infect various marine organisms as hosts. Consequently, there is a growing call to analyze the presence of infectious marine viruses from global seawater and various marine biological samples and to establish a foundation for national-level responses. The project titled “Big Data-Based Diagnosis, Treatment, and Control Technologies for Infectious Marine Viruses in the Marine Environment” has set five detailed objectives: 1) Establishing big data and data mining technologies for infectious marine viruses, 2) Developing nucleic acid- and antibody-based diagnostic technologies for infectious viruses, 3) Developing infectious virus infection models, 4) Identifying antiviral materials derived from marine organisms, and 5) Developing broad-spectrum antiviral therapeutics. Through an integrated approach to these objectives, the project aims to establish a system for early detection, diagnosis, and response to the threats posed by infectious marine viruses. The results of this research are expected to serve as a foundation for the establishment of a national observation system and response strategies for managing future viral infections originating from the marine environment and preserving marine ecosystems.

Keywords
Infectious marine viruses
Big data
Diagnostics
Infection model
Antiviral materials
Antiviral therapeutics

21세기에 들어서면서 바이러스에 의한 각종 감염병의 발생이 증가하였고, 2010년 이후로 지카바이러스, 조류 독감 바이러스 및 코로나 바이러스(사스, 메르스 등)에 의하여 인명손실 뿐만 아니라 사회 경제적인 피해가 크게 증가하였다. 특히 COVID-19는 2019년 발생하여 2020년에 전세계적인 팬데믹을 유발하고, 종식 여부를 알 수 없도록 지속되어 왔다. 세계보건기구(WHO)에서는 미래에 팬데믹을 유발할 수 있는 미지의 질병으로 ‘Disease X’를 지정하여 이에 대비하여야 함을 경고하고 있다. 해양은 전지구의 70% 이상의 면적을 차지하고 있으며, 지구생물의 80% 이상이 서식하는 것으로 알려져 있기 때문에, 다양한 해양생물을 숙주로 하는 바이러스가 육상에 비해 월등히 많을 것으로 예측되고 있다. 따라서 전세계적인 해수 및 다양한 해양생물 시료로부터 감염성 해양바이러스 존재 여부를 분석하고, 국가차원에서의 대응을 위한 기반을 구축하여야 함이 지적되고 있는 시점이다. “해양 환경 내 감염성 바이러스 빅데이터 기반 진단, 치료 및 제어기술” 연구를 위하여 5가지 세부목표를 설정하였다: 1) 감염성 해양바이러스 빅데이터 구축 및 데이터 마이닝 기술 개발, 2) 핵산 및 항체 기반 감염성 바이러스 진단기술 개발, 3) 감염성 바이러스 감염 모델 개발, 4) 해양생물 유래 항바이러스 전략 소재 개발, 5) 광범위 항바이러스 치료제 개발. 세부목표간 유기적 구성을 통하여 해양내 감염성 해양바이러스의 위험요소를 조기에 인지하고 진단하여, 향후 해양바이러스 위협으로부터 대응하기 위한 체계를 구축하고자 하였다. 본 연구의 결과는 미래 해양 유래 바이러스성 감염병 관리 및 해양생태계 보존을 위한 국가 관측시스템 구축 및 국가 대응 전략 설계의 근간으로 활용될 수 있을 것으로 기대된다.

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Information
  • Publisher :The Korean Society of Oceanography
  • Publisher(Ko) :한국해양학회
  • Journal Title :The Sea Journal of the Korean Society of Oceanography
  • Journal Title(Ko) :한국해양학회지 바다
  • Volume : 30
  • No :1
  • Pages :63-79
  • Received Date : 2025-01-08
  • Revised Date : 2025-02-12
  • Accepted Date : 2025-02-12
  • DOI :https://doi.org/10.7850/jkso.2025.30.1.063
Journal Informaiton The Sea Journal of the Korean Society of Oceanography The Sea Journal of the Korean Society of Oceanography
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